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| Analysis of pregnancy outcomes of infertile patients with adenomyosis undergoing frozen embryo transfer cycles following gonadotropinreleasing hormone agonist treatment |
| Peking University First Hospital, Beijing，100034 |
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Abstract To compare the therapeutic effect of fresh embryo transfer cycles and that of frozen-thawed embryo transfer (FET) cycles following gonadotropin-releasing hormone agonist (GnRH-a) pretreatment of infertile women with adenomyosis. Methods: The data of 55 infertile women with adenomyosis who had undergone in vitro fertilization/ embryo transfer (IVF/ET) cycles during January 2016 to December 2018 in reproductive medical centre of Peking university first hospital were analyzed retrospectively，and these women were divided into two groups. 27 women in observation group were treated with FET cycles following GnRH agonist pretreatment, and 28 women in control group were treated with fresh ET cycles. The pregnancy outcomes of women were compared in the two groups. Results: The implantation rate, clinical pregnancy rate, and live birth rate of women in the observation group were 41.1% (30/73), 70.3% (26/37), and 56.8% (21/37), respectively, which were significant higher than those (14.3% (9/63), 29.0% (9/31), and 19.4% (6/31) , respectively) of women in control group (P<0.01). There were no significant difference in ectopic pregnancy rate, miscarriage rate, preterm birth rate, twin birth rate, and low birth weight rate of women between the two groups (P>0.01). After GnRH-a pretreatment, the blood CA125 level of women in the observation group had decreased significantly, the thickness of the uterine wall had thinned significantly, and the size of adenomyoma had gotten smaller significantly（P<0.01）. Conclusion: GnRH agonist pretreatment for FET can improve pregnancy rate of patients with adenomyosis after IVF/ET.
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