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Abstract To investigate the clinical efficacy of clomiphene combined with progesterone for treating infertile women caused by polycystic ovary syndrome (PCOS), and to study its effect on ovarian function of women. Methods: 100 infertile women caused by PCOS were divided into two groups (50 cases in each group). The women in the control group were treated by clomiphene alone, and the women in the study group were treated by clomiphene combined with progesterone. The clinical efficacy of women was compared between the two groups. Results: After treatment, the endometrial thickness, the number of mature follicles, and the diameter of the largest follicles of women in the study group were significant higher than those of women in the control group, but the HMG dosage and the average treatment period of women in the study group were significant less (P<0.05). Compared with those before treatment, the T level and value of LH/FSH on HCG day of women in both groups had decreased significantly, but the E2 level had increased significantly (P<0.05). After treatment, the E2 level on HCG day of women in the study group was significant higher than that of women in the control group (P<0.05). The clinical pregnancy rate and the total effective rate of treatment of women in the study group were 56.0% and 88.0%, which were significant higher than those (28.0% and 66.0%) of women in the control group (P<0.05). There were no significant difference in the ovulation rate, abortion rate, multiple pregnancy rate, and the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Clomiphene combined with progesterone for treating infertile women caused by PCOS can promote endometrial thickening effectively, can reduce the dosage of gonadotropin used, can improve ovarian function, and can increase clinical pregnancy rate.
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