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| Analysis of reproductive tract infection situation and immune factors of women with recurrent spontaneous abortion |
| The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, 215003 |
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Abstract To explore the change of reproductive tract infection situation and immune factors of women with recurrent spontaneous abortion (RSA). Method: 50 women with RSA were selected in observation group and 50 healthy women with planning abortion were selected in control group. The bacterial copy number and infection rate of mycoplasma infection ureaplasma urealyticum (UU) and mycoplasma hominis (MH) of women in the two groups were detected. The anticardiolipin antibody (ACA)-IgM and IgG in cervical secretion and the levels of interleukin 6(IL-6), tumor necrosis factor-α(TNF-α) and bax/bcl-2 in deciduas of women in the two groups were detected. Results: The rate of UU infection in villi and decidual tissue of women in the observation group were 44.0% and 40.0%, the rate of MH in villi and decidual tissue of women in observation group were 32.0% and 30.0%, and the bacterial copy number and infection positive rate of women in observation group were 22.0% and 20.0%, which all were significant higher than those of women in the control group (P<0.05). The positive rates of aca-IgM and IgG in the vaginal secretions of women in the control group were 36.0% and 40.0%, which were significant higher than those of women in the observation group, and the expression levels of IL-6, TNF-αand bax/bcl-2 in the deciduas of women in the control group were also significant higher (P<0.05). Conclusion: The mycoplasma (UU and MH) infection, bacterial infection, ACA expression, inflammatory reaction, and apoptosis is correlation with the occurrence of RSA h, which can interact with each other.
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