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The value of the serum Vitamin A and E levels of pregnant women with preeclampsia during 28 gestational weeks for predicting their pregnancy outcomes |
| The Fourth Hospital of Wuhan, Hubei Province, Puai Hospital Affiliated to Tongji Medical College, Huazhong Science and Technology University, 430034 |
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Abstract Objective: To analyze the value of serum Vitamin (V) A and E levels of pregnant women with preeclampsia during 28 gestational weeks for predicting their pregnancy outcomes. Methods: 427 women before pregnancy (in group A) and 573 pregnant women within gestational 20 weeks (in group B, included 53 women with preeclampsia) were selected as the research objects from June 2017 to November 2018. Serum VA and VE levels and liver and kidney function of all included women were detected, and their pregnancy outcomes were statistically analyzed. Results: The average serum VA and VE levels of women during 20 gestational weeks in group B had no significant different to those of women in group A (P>0.05), but the abnormal rate of VE level of women in group B was significant lower, the rates of VA deficiency and abnormal were significant higher (P<0.05). In group B, the incidence of preeclampsia was 9.3%. In 28 gestational weeks of women in group B, the serum levels of VA and VE, the values of blood urea nitrogen (BUN) and serum creatinine (SCR) of women with mild and severe preeclampsia were significant higher than those of women without preeclampsia, and those of women with severe preeclampsia were significant higher than those of women with mild preeclampsia (P<0.05). Serum levels of VA and VE of women were negatively correlated with their values of BUN and SCR (P<0.05). The area under the ROC curve predicted by serum VA and VE levels was 0.829 and 0.915, their sensitivity were 61.9% and 65.5%, and their specificity were 92.3% and 86.9%. Conclusion: Pregnant women prone to have VA deficiency. And abnormal VA and VE levels may predicte adverse pregnancy outcomes of pregnant women with preeclampsia, so the monitoring and supplementation of VA and VE should be emphasized during pregnancy.
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