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| Analysis of the levels of vitamin A, vitamin E and helper T cell of women with earlyonset preeclampsia and the related risk factors |
| Shunyi Hospital of Beijing traditional Chinese Medicine Hospital, Beijing, 101300 |
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Abstract Objective: To observe the changes of the levels vitamin A, vitamin E and helper T cell of women with early-onset preeclampsia, and to analyze the risk factors related to early-onset preeclampsia. Methods: 2,650 normal pregnant women were included in group A between December 2016 and May 2018, which included 350 women with early-onset preeclampsia were included in group B and the other women without preeclampsia were in group A. The levels of vitamin A, vitamin E and helper T cell in peripheral venous blood of women were recorded and compared between the two groups. The suspicious factors affecting the early-onset preeclampsia were analyzed. Results: The levels of serum vitamin A and vitamin E, and the Th2 percentage of women in group B were 0.24±0.15mg/L, 4.92±0.18mg/L, and 1.04±0.17%, which were significant lower than those (0.47±0.18mg/L, 10.75±4.57mg /L, and 1.60±0.29%) of women in group A, but the Th 1 percentage and Th1/Th2 value of women in group B were 21.01±3.96% and 20.41±5.75, which were significant higher than those (12.31±2.50% and 7.93+1.46) of women in group A (all P<0.05). Multiple pregnancy, age ≥35 years old, medical complications, vitamin E deficiency, and prenatal BMI abnormalities were independent risk factors of early-onset preeclampsia. Conclusion: The pregnant women with early-onset preeclampsia lack vitamin A and vitamin E, and have the immune balance disorder. Multiple pregnancy, age ≥35 years old, medical complications, lack vitamin E, and abnormal prenatal BMI are independent risk factors of early-onset preeclampsia, so it should be paid more attention in clinic practice.
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