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| Application of blood flow spectrum for predicting the prognosis of women with early-onset preeclampsia |
| 1.The 81st Group Army Hospital of land force, Zhangjiakou, Hebei Province, 075000；2. The First Hospital of Zhangjiakou City |
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Abstract Objective: To explore the value of blood flow spectrum for predicting the pregnancy outcomes of women with early-onset preeclampsia. Methods: The clinical data of 120 women with early-onset pre-eclampsia (in study group) and 100 pregnant women without pre-eclampsia (in control group) were collected retrospectively. The changes of blood flow spectrum of uterine artery and umbilical artery of women in the two groups were examined by three-dimensional color Doppler ultrasound during the third trimester of pregnancy. The women in the study group were also divided into group A (with infant adverse outcomes), group B (with maternal adverse outcomes), and group C (without adverse pregnancy outcomes) according to the pregnancy outcomes, and the blood flow spectrum of women was compared among the four groups. The receiver operating characteristic (ROC) curve was used to analyze the efficacy value of the blood flow spectrum for predicting adverse pregnancy outcomes. Results: The S/D, PI and RI values of the uterine artery of women in the study group were significant higher than those of women in the control group, the incidences of perinatal infant and maternal adverse outcomes were 28.3% and 21.7%, which were significant higher than those (5.0% and 4.0%) of women in the control group (P<0.05). In the study group, the S/D, PI and RI values of uterine artery and umbilical artery of women with adverse pregnancy outcomes were significant higher than those of women without adverse pregnancy outcomes (P<0.05). The S/D, PI and RI values of uterine artery and umbilical artery of women with early-onset preeclampsia could predicted the adverse pregnancy outcomes effectively, which sensitivity and specificity were 75%-80% and of 83%-86%. Conclusion: There is a close relationship between the changes of blood flow spectrum of uterine artery and umbilical artery of women with earlyonset preeclampsia and their maternal and infant prognosis. Monitoring the blood flow spectrum of uterine artery and umbilical artery can provide an effective evidence for predicting maternal and infant adverse outcomes.
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