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| Clinical efficacy of basal FSH as progestin primed ovarian stimulation protocol for treating women with diminished ovarian reserve |
| Reproductive Medical Center of People’s Hospital of Wuhan University, Hubei Clinical Research Center for Assisted Reproductive and Embryonic Development, Wuhan, Hubei Province, 430060 |
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Abstract Objective: To explore the influence of basal FSH (bFSH) as progestin primed ovarian stimulation (PPOS) protocol for treating women with diminished ovarian reserve (DOR) on their outcomes of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Methods: The data of 328 women with DOR under PPOS from June 2016 to November 2017 were analyzed retrospectively, and these women were divided into Group A (women were given bFSH <10 IU/L) and Group B (women were given bFSH≥10 IU/L) according to the dosage of bFSH used. The baseline information, ovarian stimulation characteristics, and laboratory outcome of embryo of women in the two groups were collected and analyzed. Results：The value of bLH of women in group B was 5.0±1.8, which was significant higher than that (2.5±1.5) of women in group A (P<0.001), and the value of bE2 of women in group B 168.4±183.4, which was significant lower than that (231.0±228.8) of women in group A (P<0.01). The numbers of follicle >14mm and oocytes of women in group B on hCG day were 2.8±1.7 and 3.0±2.1, which were significant lower than those (3.4±2.1 and 3.9±2.7) of women in group A (P<0.05). However, there were no significant different in the mature egg rate, 2PN fertilization rate, 2PN cleavage rate, high-quality embryo rate, transplantable embryo rate, high-quality embryo number, and utilized embryo number of women between the two groups (P> 0.05). There was no difference in clinical pregnancy rate in frozen embryo transfer of women between the two groups (P>0.05). Conclusion：PPOS protocol is benefit for women with DOR, especially for those women with high bFSH, which has potential application value.
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