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| Expression of mitogen-activated protein kinase 4, PKG1 and ZlC1 in endometrial carcinoma tissue of patients and their value for predicting prognosis of patients |
| Affiliated Hospital of Yan'an University, Shaanxi Province, 716000 |
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Abstract Objective: To analyze the expression levels of mitogen-activated protein kinase 4 (MAP2K4), PKG1 and ZlC1 in endometrial carcinoma tissue of patients, and to study their value for predicting prognosis of patients. Methods: 112 patients with endometrial cancer were enrolled in study group and 103 patients with benign uterine lesions were enrolled in control group from January 2012 to January 2014. Immunohistochemical method was used to detect MAPK4, PKG1 and ZlC1 levels in the endometrial carcinoma tissue of patients. The patients were followed up for 5 years, and their survival situation was recorded. Logistic regression model was used to analyze the relationship between MAP2K4, PKG1 and ZlC1 expression levels and the prognosis, and ROC curve was used to analyze the value of the expression levels of MAP2K4, PKG1 and ZlC1 for predicting the prognosis of patients. Results: The expression levels of MAP2K3, PKG1 and ZIC1 of patients in the observation group were significant higher than those of patients in the control group, and which of died patients were significant higher than those of survival patients (P<0.05). The survival time of patients with low expression of MAP2K3, PKG1 and ZIC1 was significant higher than that of patients with high expression of MAP2K3, PKG1 and ZIC1 (P<0.05). The levels of MAP2K3, PKG1 and ZIC1 were the independent factors affecting the prognosis of patients (P<0.05), which’s sensitivity and specificity for predicting the prognosis of patients were more than 80.0%, and the AUC was more than 0.9. Conclusion: The levels of MAP2K4, PKG1 and ZlC1 in endometrial carcinoma tissue of patients are abnormally high, which may be used as an indicator for evaluating the prognosis of patients with endometrial carcinoma.
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