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| The effect of tumor necrosis factor-α, interleukin-10, and tumor necrosis factor alpha-induced protein-2 on maternal-fetal immune regulation#br# |
| 1. Maternal and Child Health Care Hospital of Yuci District, Jinzhong City, Shanxi Province, 030600; 2. Graduate School of Shanxi Medical University; 3. Shanxi Maternal and Child Health Care Hospital |
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Abstract Objective: To investigate the effect of tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), and tumor necrosis factor alpha-induced protein-2 (TIPE2) on maternal-fetal immune regulation. Methods: Immunohistochemistry was used to detect the expression levels of TIPE2, TNF-α and IL-10 in the villus tissues of 30 women with recurrent spontaneous abortion (study group) and 33 women with unwanted pregnancy after artificial abortion (control group). Results: The expression rate of TNF-α in the villus tissue of women in the study group was 63.3%, which was significant higher than that (30.3%) of women in the control group, the expression rates of IL-10 and TIPE2 were 6.7% and 23.3%, which were significant lower than those (60.6% and 57.6%) of women in the control group. TIPE2 level was negatively correlated with TNF-αlevel (r=0.752, P<0.05), and TIPE2 level was positively correlated with IL-10 level (0.915, P<0.05). Conclusion: TIPE2 maybe correlated with the balance of Th1/Th2 of maternal-fetal interface in the mechanism of recurrent abortion.
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