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| The value of serum VEGF, PlGF and sFlt-1 levels of pregnant women during the third trimester pregnancy for predicting placenta accrete |
| The Second People's Hospital of Nanyang City, Henan Province, 471000 |
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Abstract Objective: To analyze the value of serum VEGF, PlGF and sFlt-1 levels of pregnant women during the third trimester pregnancy for predicting placenta accrete. Methods: The pregnant women with high risk factors of placenta accrete were selected as subjects from January 2014 to December 2018. According to postpartum diagnostic results, the included women were divided into group A (women without placenta accrete), group B (women suspected placenta accrete), and group C (women with placenta accrete). In addition, all women were further divided into group C 1 (women with placental adhesion) and group C 2 (women with placenta increta) according to the depth of villi invasion. The difference of serum levels of VEGF, PLGF and sFlt-1 of pregnant women and their value for predicting placenta accrete were compared among these groups. Results: The serum levels of VEGF and PLGF of women in group C were significant higher than those of women in group A and B, and sFlt-1 level of women in group C was significant lower (P<0.05). There were no statistically significant differences in levels of VEGF, PLGF and sFlt-1 of women between group A and B (P>0.05). The serum levels of VEGF and PLGF of women in group C 2 were significant higher than those of women in group C 1 (P<0.05), but there were no significant difference in sFlt-1 level of women between group C 1 and C 2 (P>0.05). ROC curve analysis showed that VEGF and PLGF levels had values for predicting placenta accrete (P<0.001). The area under ROC curve, sensitivity, and the specificity of VEGF level were 0.812, 83.1%, and 66.7%, respectively. The area under ROC curve, the sensitivity, and the specificity of PLGF level were 0.749, 86.2%, and 60.3%, respectively. While sFlt-1 level had no value for predicting placenta accrete (P>0.05). Conclusion: The levels of serum VEGF, PLGF and sFlt-1 of pregnant women with placenta accrete during the third trimester pregnancy are abnormal, in which, the levels VEGF and PLGF have some value for predicting placenta accrete and can help for predicting depth of villi invasion.
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