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Abstract Objective: To investigate the influence of general anesthesia combined with epidural anesthesia on the level of related factors of women with gynecologic laparoscopic surgery. Methods: 94 women who planned to undergo gynecologic laparoscopic surgery laparoscopic were divided randomly into control group and observation group (47 cases in each group) from May 2016 to May 2018. The women in the control group had received general anesthesia, and the women in the observation group had received general anesthesia combined with epidural anesthesia. The indexes of stress response, coagulation function, endocrine and immune, and other indexes of women before anesthesia (T1), during pneumoperitoneum (T2), and 10min before operation end were measured and compared between the two groups. Results: At T1, there were no significant difference in the indexes between the two groups (P>0.05). At T2 and T3, there were significant differences in levels of stress response index (SOD, MDA, ET-1), coagulation function (APTT, PT, PLT, D-Dimer), endocrine index (NE, Cor, Ins, C-P, FT3, FT4), immune index(CD3+, CD4+, CD8+), and other related indexes (TXB2, 6-K-PGF1α, TXB2/6-K-PGF1α) of women between the two groups (P<0.05). Conclusion: General anesthesia combined with epidural anesthesia during gynecologic laparoscopic surgery can significantly improve related indicators, such as stress, coagulation, endocrine and immunity of women, which are more beniffit to the stability of vital signs, and can improve the operation smoothly.
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