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| The clinical eficacy of mifepristone and mirena for treating women with perimenopausal abnormal uterine bleeding caused by ovulatory disorders |
| 363 Hospital，Chengdu, Sichuan Province, 610041 |
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Abstract Objective: To investigate the clinical eficacy of mifepristone and mirena for treating women with perimenopausal abnormal uterine bleeding caused by ovulatory disorders (AUB-O). Methods: 94 women with perimenopausal AUB-O were selected as the subjects from Nov 2015 to Nov 2017, and were divided into control group and observation group by the random number table (47 cases in each group). Women in the control group were treated by mifepristone tablets, and women in the observation group were inserted in mirena. The total effective rate, control bleeding time, complete hemostasis time, the changes of endometrial thickness and sex hormone levels before and after 3 months of treatment, and the rate of adverse reactions of women in the two groups were observed. Results: The total effective rate of women in the observation group was 93.6%, which was significant higher than that (78.7%) of women in the control group (P<0.05). The control bleeding time and complete hemostasis time of women in the observation group were 29.6±4.4 h and 65.4±7.2 h, which were significant shorter than those (33.8±4.4 h and 69.9±7.3 h) of women in the control group (P<0.05). After 3 months of treatment, the endometrial thickness, and the levels of serum estradiol (E2), luteinizing hormone (LH) and follicle stimulating hormone (FSH) of women in the observation group were significant lower than those of women in the control group (P<0.05). The incidence of adverse reactions during the treatment of women in the observation group was 12.8%, which was significant higher than that (29.8%) of women in the control group (P<0.05). Conclusion: The mirena used for treating perimenopausal AUB-O can hemostasis rapidly, improve endometrium, regulate the level of sex hormone, which’s curative effect is better than mifepristone with more safety, so it is worthy of popularization.
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