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Abstract Objective: To investigate the influence of compound Danshen injection combined with low-molecular-weight heparin (LMWH) for treating women with early onset severe preeclampsia (ESPE) on their heart kidney function, and to study its mechanism. Methods: From January 2016 to December 2017, 120 women with ESPE were enrolled and randomly divided into the observation group and the control group (60 cases in each group). The women in the both groups had received routine treatment, the women in the control group were given LMWH, and the women in the observation group were given compound Danshen injection combined with LMWH. The pregnancy outcomes were compared between the two groups. The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart and kidney function indexes left ventricular ejection fraction (LVEF),cardiac index (CI), brain natriuretic peptide (BNP), troponin T (cTnT), 24 h urine output, 24 h urine protein (UP), serum creatinine (Cre), blood urea nitrogen (BUN), high mobility B1 protein (HMGB1), soluble vascular endothelial growth factor receptor 1 (sFLt-1), placental growth factor (PIGF), von Willebrand factor (vWF), p-selectin (Ps) of women in both groups were detected before and after treatment. Results: There were no significant difference in SBP and DBP of women after treatment between the two groups (P>0.05). After treatment, the levels of LVEF, APTT, PT and PIGF, and 24h urine output of women in the observation group were significant higher than those of women in the control group, while the CI and levels of BNP,cTnT,24hUP,Cre,BUN, D-D,FIB,HMGB1,sFlt-1,vWF,and Ps of women in the observation group were significant lower (P<0.05). There was no significant difference in the duration of pregnancy between the two groups (P>0.05), while the rates of cesarean section, and maternal and infant adverse pregnancy outcomes in the observation group were significant lower than those in the control group (P<0.05). Conclusion: Compound Danshen injection combined with LMWH for treating women with ESPE early onset severe preeclampsia can improve the pregnancy outcomes, and its mechanism possibly related to protect or improve the cardiac and renal function, and regulate blood pressure of pregnant women by adjusting the sfit-1 /PIGF balance and HMGB1, vWF and Ps levels, which is related to prevent inflammatory damage and protect vascular endothelial function.
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