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| The influence of E2 level decreased on the outcomes of IVF-ET of the women with controlled ovarian hyperstimulation by long protocol at early follicular stage |
| The Third Hospital Affiliated to Zhengzhou University, Henan Province, 450052 |
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Abstract Objective: To influence of falling estradiol (E2) level decreased on the outcomes of In vitro fertilization-embryo transfer (IVF-ET) of the women with controlled ovarian hyperstimulation (COH) by long protocol at early follicular stage. Methods: The clinical data of patients with E2 level decreased (in study group) and the patients with E2 level increased (in control group) during controlled ovarian hyperstimulation (COH) were retrospective analyzed. The pregnancy outcomes of women were compared. Results: The E2 level on HCG day of women in study group was significant lower than that of women in control group. And In study group, the E2 level of women without Gn decreased was significant lower than that of women with Gn decreased (P<0.05), and the degree of E2 level decreased, the number of retrieved oocytes, and the rate of 2PN of women with Gn decreased were significant lower than those of women without Gn decreased (P<0.05). There were no significant differences in level of P on HCG day, 2PN cleavage rate, high quality embryo rate, embryo number of transplantation, clinical pregnancy rate, and early abortion rate between the two groups (P>0.05). The 2PN cleavage rate or high quality embryo rate of women with over 20% E2 level decreased on HCG day was highest (P<0.05). Conclusion: When the spontaneous decreasing of E2 level of women with COH by long protocol is over 20%, it maybe reduce the number of retrieved oocytes and rate of high quality embryo, but it hasn’t influence on the clinical pregnancy rate.
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