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| The curative effect of interferon gel combined with Baofukang suppository for treating women with CIN Ⅲ after Loop electrosurgical excisional procedure and its influence on the level of inflammatory factors |
| Anda Hospital of Shanghai, Shanghai, 201204 |
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Abstract Objective: To observe the curative effect of interferon gel combined with Baofukang suppository for treating women with CIN Ⅲ after Loop electrosurgical excisional procedure (LEEP), and to analyze its influence on the level of inflammatory factors of women. Methods: 176 women with CIN Ⅲ who had experienced LEEP were as the research objects from May 2017 to September 2015. All the women were divided into control group (n=88) and study group (n=88) according to random number table. The women in control group were treated by Baofukang suppository, and the women in study group were treated by Baofukang suppository combined interferon gel. The serum levels of TNF-α and hs-CRP of all women were detected at 1 month after LEEP operation. The wound healing time of all women was counted. The curative effect, the rate of high risk HPV turned to negative, postoperative complication rate, and the recurrence rate of CIN within 1 years after treatment were compared between the two groups. Results: The healing time of the cervical wound of women (17.5±3.6d) in study group was significant shorter than that (25.2±4.2 d) of women in control group (P=0.000). 1 month after LEEP, the serum levels of TNF-α and hs-CRP were significantly decreased, and the serum levels of TNF-α and hs-CRP of women in study group were significant lower than those of women in control group (P<0.05). There was no significant different in the effecti-e rate (94.3% VS. 95.5%) between the two groups (P=0.732>0.05). The rate of high risk HPV turned to negative of women in study group (92.9%) was significant higher than that(66.2%) of women in control group (P=0.000). The incidence of postoperative complications (8.0%) and CIN recurrence rate during 1 year (2.41%) of women in study group were significant lower than those (19.3% and 11.9%) of women in control group (P=0.028, 0.018). Conclusion: Interferon gel combined with Baofukang suppository for treating women with CIN Ⅲ after LEEP can significantly decrease the inflammation reaction degree, shorten wound healing time, promote the high-risk HPV turned to negative, and reduce the risk of complications and recurrence of CIN, so it is worthy of gynecology clinical application.
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| Cite this article: |
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ZHANG Jiazhen. The curative effect of interferon gel combined with Baofukang suppository for treating women with CIN Ⅲ after Loop electrosurgical excisional procedure and its influence on the level of inflammatory factors[J]. 中国计划生育学杂志, 2019, 27(5): 608-.
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| URL: |
| https://www.zgjhsyx.com/EN/ OR https://www.zgjhsyx.com/EN/Y2019/V27/I5/608 |
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