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| Application of sevoflurane combined with remifentanil in cesarean section and its effect on plasma inflammatory cytokines |
| Oingdao Municipal Hospital, Qingdao, Shandong Province, 266011 |
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Abstract Objective: To analyze the effect of sevoflurane combined with remifentanil in cesarean section, and to analyze its influence on plasma inflammatory cytokines. Methods: 91 women who wanted cesarean section were divided into control group (48 cases) and observation group (43 cases) according to random number table method. The women in control group were given anesthesia by propofol combined with remifentanil, and the women in observation group were given anesthesia by sevoflurane combined with remifentanil. The situation of anesthetic recovery, plasma inflammatory cytokines levels, hemodynamics value, neonatal Apgar score, volume of intraoperative or postoperative blood loss, and adverse reactions rate of women were compared between the two groups. Results: The time of spontaneous breathing recovery, removal tube, and eye opening of women in observation group were significant shorter than those of women in control group (P<0.05). The levels of plasma inflammatory cytokines of all women increased after cesarean, and the levels of plasma inflammatory cytokines of women in observation group were significant lower than those of women in control group (P<0.05). After surgery, the hemodynamic indexes of women in both groups decreased significantly, while that of women in observation group decreased more (P<0.05). There were no significant different in Apgar score of newborns, volume of intraoperative or postoperative blood loss in 24h after operation, and rate of adverse reaction between the two groups (P>0.05). Conclusion: Sevoflurane combined with remifentanil used in cesarean section can inhibit the release of inflammatory cytokines, improve security of mothers and babies, so it can be used as one of safe and effective anesthetic methods for cesarean section.
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