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Abstract To investigate the relationship between thyroid dysfunction of pregnant women and their gestational diabetes mellitus (GDM) and hypertension occurred. Methods: A total of 600 pregnant women were enrolled in the study, and they were divided into group A (300 cases with normal pregnancy), group B (40 cases with hyperthyroidism), group C (120 cases with hypothyroidism), and group D (140 cases with subclinical hypothyroidism). The serum levels of TSH, FT4, fasting blood glucose (FPG), postprandial 2h glucose level (2h PG), glycosylated hemoglobin (HbA1c), and 24h urine protein, and the values of insulin resistance index (HOMA-IR), systolic blood pressure (SBP), and diastolic Pressure (DBP) of all included women detected. The rates of GDM and HDP of pregnant women with different thyroid function states were analyzed. Results: The serum levels of FPG,2h PG, HOMA-IR, HbA1c, TG, TC, HDL, and 24h urine protein, and the values of HOMA-IR, SBP, and DBP of women in group A and B were significant higher than those of women in group C and D (P<0.01). There was no significant different in level of LDL of women among the four groups (P>0.05). Spearman correlation analysis showed that subclinical hypothyroidism was positively correlated with GDM and HDP prevalence (P<0.05). The risk of GDM of women in group C and D were 3.0 and 3.7 times that of women in group A (P<0.05), and the risk of HDP of women in group C and D were 1.4 and 1.8 times that of women in group A (P<0.05). Conclusion: Pregnant women with thyroid dysfunction, especially with hypothyroidism or subclinical hypothyroidism, have a high risk of GDM and HDP, which needs to be paid more attention to, and should be prevented.
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