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| Expressions of C-kit and PI3K in uterine scar tissue and its relationships with uterine scar healing |
| Linhai Maternal and Child Health Care Hospital, Zhejiang Province, 317000 |
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Abstract To investigate the expressions of stem cell factor receptor (c-kit) and phosphotyl inosital 3 kinase (PI3K) in uterine scar tissue, and to study their relationships with uterine scar healing. Methods: 110 pregnant women underwent cesarean sections again were selected into the study group, and 25 pregnant women underwent cesarean section at the first time were selected into control group. The women in study group were also divided into group A (87 cases with healed well of uterine scar) and group B (23 cases with undesirable healing of uterine scar) according to the condition of uterine scar healing during cesarean section again. Real time fluorescent quantitative PCR (qRT-PCR) and immunohistochemistry were used to detect the relative expressions of c-kit and PI3K of all included women. The influencing factors of uterine scar healing were analyzed by Logistic analysis. Results: The expressions and the levels of of c-kit and PI3K of women with history cesarean section <3 years or≥8 years were significant higher than those of women in control group (P<0.05). The rates and levels of positive expressions of c-kit and PI3K expressions of women with undesirable healing of uterine scar after cesarean section after operation 3-4 years were the lowest (P<0.05). And the levels of positive expressions of c-kit and PI3K of women with undesirable healing of uterine scar were significant higher than those of women with healed well of uterine scar (P<0.05). Logistic analysis showed that the levels of c-kit and PI3K were risk factors for uterine scar healing. Conclusion: The expression levels of c-kit and PI3K in uterine scar tissue can promote uterine scar healing, but their over expressions are not benefit for uterine scar healing, 3-4 years after cesarean section is the best period for uterine scar healing.
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