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Abstract To study the expression levels of serum micro RNA-210 (miR-210) and micro RNA-126 (miR-126) of patients with ovarian cancer, and to explore the relationships between the levels of miR-210 and miR-126and the clinicopathological features and prognosis of the patients. Methods: 102 patients with ovarian cancer were selected in study group, and another 102 healthy female volunteers were selected in control group. The expression levels of serum miR-210 and miR-126 of women in the two groups were detected by qRT-PCR, and women in study group were divided into high expression group and low expression group according to the median value of the levels of serum miR-210 and miR-126. Receiver operating characteristic curve (ROC) was used to analyze the predictive values of miR-210 and miR-126 expressions, Kaplan-Meier was used to analyze the survival of patients with ovarian cancer, and Logistic multiple regression analysis was used to analyze the risk factors of ovarian cancer. Results: Compared with the control group, the expression level of serum miR-210 of patients in study group increased (P<0.05), but the expression level of miR-126 was decreased significantly (P<0.05). MiR-210 and miR-126 levels were significantly correlated with lymph node metastasis, FIGO stage, degree of differentiation, and the serum carbohydrate antigen 125 (CA125) level of patients (P<0.05), and miR-210 level was significantly correlated with histological type (P<0.05). ROC analysis showed that the area under curve (AUC) of miR-210 level and miR-126 level were 0.789 and 0.836, respectively, their sensitivity were 96.61% and 67.80%, respectively, and their specificity were 51.16% and 95.35%, respectively. Kaplan-Meier analysis showed that PFS and OS of patients in miR-210 low expression group were significant higher than those of patients in miR-210high expression group (P<0.05), but FS and OS of patients in miR-126 high expression group were significant higher than those of patients in miR-126 low expression group (P<0.05). Logistic analysis showed that both miR-210 and miR-126 levels were independent risk factors for the occurrence of ovarian cancer. Conclusion: The expression of serum miR-210 patients with ovarian cancer has up-regulated, while the expression of miR-126 has down-regulated, which all are related to the occurrence and development of ovarian cancer, and can be used as an important indicators of clinical diagnosis, monitoring and evaluating prognosis of the disease.
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