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| The significances of level of serum and urine NGAL detection of pregnant women with chronic glomerulonephritis during pregnancy |
| 1. Heping District Obstetrics and Gynecology Hospital of Tianjin, Tianjin, 300041；2. General Hospital of Tianjin Medical University |
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Abstract To investigate the significance of level of serum and urine neutrophil gelatinase associated lipoprotein (NGAL) detection of pregnant women with chronic glomerulonephritis during pregnancy. Methods: 74 pregnant women with chronic glomerulonephritis from February 2016 to February 2017 were selected in observation group, and 58 normal healthy pregnant women were selected in control group. Enzyme-linked immunosorbent assay was used to determine the level of NGAL in serum and urine of women, and the values of creatinine (Scr), urea nitrogen (BUN), 24-hour urinary protein (24-Upro) and glomerular filtration rate (GFR) were also measured. Pearson correlation analysis was used to analyze the correlation between serum and urine NGAL levels, and their relationships with values of Scr and BUN and 24-Upro. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of serum and urine NGAL levels. Results: The values of Scr, BUN and 24-Upro of women in observation group were significant higher than those of women in control group, while GFR of women in observation group was significant lower than that of women in control group (P<0.05). The levels of serum and urine NGAL of women in observation group were significant higher than those of women in control group (P<0.05).The level of serum NGAL was positive correlation with level of urine NGAL. And the levels of serum and urine NGAL were positive correlation with values of Scr, BUN and 24-Upro, and were negative correlated with value of GFR (P<0.05).The diagnostic significance of urine NGAL level was higher than that of serum NGAL level. The truncated value of serum NGAL level was 389.9ng/ml, and its sensitivity, specificity and Jorden index was 86.7%, 69.5% and 0.562, respectively. The truncated value of urine NGAL level was 392.0ng/ml, and its sensitivity, specificity and Jorden index was 86.7%, 76.3% and 0.6, respectively. Conclusion: The levels of serum and urine NGAL of pregnant women with chronic nephritis abnormally increase, and the diagnostic value of urine NGAL level is higher than that of urine NGAL level. The clinical detection of serum and urine NGAL levels is benefit for diagnosis and treatment of patients timely, and it is important for improving patient’s prognosis.
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