Abstract To investigate the effect of propofol combined with sufentanil and its influence on hemodynamics of women experienced painless induced abortion. Methods: 176 women experienced painless induced abortion were divided into two groups randomly. 88 women in study group were anesthetized by propofol combined with sufentanil, and 88 women in control group were anesthetized by propofol combined with fentanyl. The heart rate (HR) and mean activity (mean HR) before operation (T0), 2 minutes (T1) after operation and at the end of operation (T2) , and the changes of pulse pressure (MAP) and blood oxygen saturation (SPO2) of women were compared between the two groups. And the dosage of propofol used during operation, the incidence of physical activity, the time of awakening after operation and the degree of postoperative uterine contraction pain of women were also compared between the two groups. Results: The proportion of anesthesia grade I of women in study group was significant higher than that of women in control group (73.9% VS 59.1%, P<0.05). The dosage of propofol used during operation, the incidence of physical movement and the postoperative waking time, the postoperative uterine contraction pain VAS score, and the incidence of adverse reactions of women in study group were significant lower than those of women in control group ［(132.51±22.62) mg VS (161.62±29.51) mg, 6.82% VS 17.05%,(1.52±0.73) min VS (2.85±0.95) min, 3.4% VS 11.4%,P<0.05］. HR and MAP at the baseline of T2 of women in study group were significant higher than those of women in the control group ［(77.05±6.74) VS (74.05 ±5.54)/min, (89.02±10.17) mmHg VS (82.21±10.08) mmHg, P<0.05］. Conclusion: For painless induced abortion, propofol combined with sufentanil maybe influence little on hemodynamics, which can reduce the incidences of intraoperative restlessness and adverse reactions, promote postoperative recovery, alleviating postoperative pain caused by uterine contraction.
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