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Abstract To investigate the value of levels of serum vascular endothelial growth factor (VEGF) and adipocyte fatty acid binding protein (FABP4) for diagnosing renal damage early of pregnant women with gestational diabetes mellitus (GDM). Methods: Sixtythree patients with GDM were selected in study group, and 42 normal pregnant women were in control group. In study group, the pregnant women were also divided into normal proteinuria group (16 cases, UAER<20 μg/min). microalbuminuria group (23 cases, 20 μg/min<UAER<200 μg/min), large proteinuria group (24 cases, UAER>200 μg/min) based on the urinary albumin excretion rates (UAER). The levels of serum VEGF and FABP4 of all included women were detected and compared. The testworker characteristic curve (ROC) was used to analyze the efficacy of VEGF and FABP4 levels for diagnosing the renal damage early of pregnant women with GDM. Results: The serum VEGF, FABP4 levels of pregnant women in large proteinuria group were significant than those of pregnant women in microalbuminuria group, and the serum VEGF, FABP4 levels of pregnant women in microalbuminuria group were significant than those of pregnant women in normal proteinuria group (P>0.05). The positive rates of VEGF, FABP4 detection of pregnant women in microalbuminuria group were significant higher than those of pregnant women in normal proteinuria group (P>0.05).The sensitivity, specificity, accuracy, and area under the curve (AUC) of detection of level VEGF for diagnosing renal damage early of pregnant women with GDM were 72.4%, 72.3%, 79.4%, 0.617 (95% CI: 0.729-0.931) , respectively, and the sensitivity, specificity, accuracy, and area under the curve (AUC) of detection of FABP4 level for diagnosing renal damage early of pregnant women with GDM were 79.4%、72.8%、81.8%、0.729 (95%CI:0.617-0.872), respectively. And the sensitivity, specificity, accuracy, and area under the curve (AUC) of detection of level VEGF combined with detection of FABP4 level for diagnosing renal damage early of pregnant women with GDM were 89.4%, 82.8%, 83.8%, and 0.894 (95%CI:0.829-0.941), respectively. Conclusion: Serum levels of VEGF and FABP4 in peripheral blood of pregnant women with GDM and renal damage early may increase significantly, so the detection of serum VEGF and FABP4 levels can help to diagnose renal damage early of pregnant women with GDM, which can provide evidence for clinical diagnosis and treatment.
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