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| Study of the association between methylenetetrahydrofolate reductase C677T polymorphrism and the hyperhomocysteinemia concentrations of pregnant women during the first trimester of pregnancy |
| 1.Wenzhou Medical University, Zhejiang Province, 325000; 2. Wenzhou Hospital of Traditional Chinese Medicine |
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Abstract To investigate the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphrism and the level of hyperhomocysteinemia of pregnant women during the first trimester of pregnancy in Wenzhou city. Methods: 1052 pregnant women during the first trimester pregnancy who had admitted to Wenzhou hospital of traditional Chinese medicine from June 2015 to July 2016 were selected. The MTHFR genotypes of all included women were detected by fluorescence PCR, and levels of serum hyperhomocysteinemia of all women were detected by enzymatic cycling. Results: Among the 1052 pregnant women, 443 cases (42.1%) were the genotype of CC, 469 cases were the genotype of CT (44.6%), and 140 cases were the genotype of TT (13.3%), respectively. The allele gene frequencies were 64.4% (n=1355) for C and 35.6% (n=749) for T, respectively, which had the characteristic gene frequency of Wenzhou women, and was different from that of women from most of other regions. The levels of hyperhomocysteinemia of women with CC、CT、TT genotype were (5.8±1.5)μmol/L, (5.7±1.2)μmol/L, and (6.4±2.7)μmol/L, respectively. The level of hyperhomocysteinemia of women with TT genotype was significant higher than that of women with CC genotype or CT genotype. Conclusion: In Whenzhou area, MTHFR C677T polymorphrism of pregnant women is associated to the level of hyperhomocysteinemia. The women carrying TT genotype should be played close attention from the first trimester pregnancy, and their folic acid supplementation should be strengthened.
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