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Abstract To investigate the clinical efficacy and mechanism of vitamin D (VitD) combined with double-C regimen for treating pregnant women with gestational diabetes mellitus (GDM). Methods: 106 pregnant women with GDM were randomly divided into observation group (n=53) and control group (n=53). The pregnant women in observation group received VitD combined with double-C therapy, and the pregnant women in control group received double-C therapy only. The blood glucose control effect, time of blood glucose returned to normal, dosage of insulin used of pregnant women was compared between the two groups. The homeostasis model-insulin resistance index (HOMA-IR), and levels of tumor necrosis factor-α (TNF-α), adiponectin (APN), visfatin, retinol binding protein 4 (RBP4) of all included pregnant women were measured before and after treatment. Results: After treatment, there were no significant different in levels of fasting blood glucose (FBG) and postprandial 2h blood glucose (2h PG), the incidence of hypoglycemia, and rate of dawn phenomenon of pregnant women between the two groups (P>0.05), while the levels of lycosylated hemoglobin hbalc (HbAlc) and fasting insulin (FINS), HOMA-IR, and rang of blood glucose fluctuations of pregnant women in observation group were significant lower than those of pregnant women in control group (P<0.05).And the time of blood glucose returned to normal and dosage of insulin used of pregnant women in observation group were significant lower than those of pregnant women in control group (P<0.05). After treatment, the serum levels of TNFα, visfatin and RBP4 of pregnant women in observation group were significant lower than those of pregnant women in control group, while APN level of pregnant women in observation group was significant higher than that of pregnant women in control group (P<0.05). Conclusion: VitD combined with double-C therapy for treating pregnant women with GDM can improve clinical efficacy by up-regulating APN and down-regulating TNF-α, visfatin and RBP4.
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