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| Clinical study of the influence of reproductive endocrine hormone, serum levels of ET and NO on the semen quality of diabetic males |
| Hebei Research Institute of Family Planning Science and Technology, Key Laboratory of the National Commission of Health and Family Planning for Family Planning and Healthy Birth, Shijiazhuang, Hebei Province,050071 |
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Abstract To analyze the changes of reproductive endocrine hormones, serum levels of ET and NO of diabetic males, and to explore the influence of reproductive endocrine hormone, serum levels of ET and NO on the semen quality of diabetic males. Methods: 157 man were divided into normal group (n=70), fasting glucose impaired group (n=58), and diabetic group (n=29) according to their fasting blood glucose level. The serum levels of follicle stimulating hormone (FSH), leutelnizing hormone (LH), testosterone (T), estradiol (E2), prolactin (PRL) of all included men were measured by the chemiluminescence immune assay, and the serum levels of the ET and NO were measured by the ELASA. Semen samples were collected by masturbation, and semen volumes were recorded. CASA system was used to analyze sperm concentration, total number of sperm and progressively motile sperm (PR%). Results: Compared with those of men in normal group, the levels of sperm concentration, total sperm count, PR%, serum levels of T and NO of men in diabetic group were significant lower (P<0.05), but serum levels of FSH, LH and ET of men in diabetic group were significant increased (P<0.05), and there were no significant different in semen volume, serum levels of E2 and PRL (P>0.05). There were no significant different in semen volume, sperm concentration, total sperm count, and the serum levels of FSH, LH, T, E2, PRL, ET and NO (P>0.05) between normal group and fasting glucose impaired group, but PR% of men in fasting glucose impaired group was significant lower than that of men in normal group (P<0.05). Conclusion: Diabetes can damage the reproductive system of male and can cause endocrine and endothelial dysfunction, which is the main cause of the decline in semen quality.
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