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| The detection of serum B cell activating factor of pregnant women with hypertensive disorder complicating pregnancy (HDCP) and its clinical significance |
| Nantong Ruici Hospital, Nantong, Jiangsu Province, 226000 |
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Abstract Objective:To explore the level of serum B cell activating factor of pregnant with hypertensive disorder complicating pregnancy (HDCP), and to investigate its clinical significance. Methods: 92 pregnant women with HDCP in Nantong ruici hospital from March 2014 to February 2016 were selected into research group, and another 87 normal pregnant women during the same period were selected into control group. Enzyme-linked immunosorbent assay was used to detect the serum BAFF level of all pregnant women. The whole blood cell analyzer and Automatic Coagulation Analyzer were used to detect the blood indexes, such as blood coagulation indexes and platelet indexes. The correlations between serums BAFF with blood indexes of pregnant women were compared between the two groups, receiver operating characteristic curve (ROC) was used to analyze the diagnostic value of serum BAFF level, and multiple logistic regression analysis was also used for analyzing the risk factors of adverse outcomes of pregnant women with HDCP. Results: Compared with pregnant women in control group, the coagulation index, such as the values of PT and APTT of pregnant women in research group were significantly decreased (P<0.05), but the FIB was significantly increased (P<0.05). The platelet indexes, such as the values of PLT and PCT of pregnant women in research group were significantly decreased (P<0.05), but the values of MPV and PDW were significantly higher (P<0.05). The serum BAFF level of pregnant women in research group was significantly higher than that of pregnant women in control group (P<0.05). Pearson correlation analysis showed that there was a significant positive correlation between serum BAFF level with the value of PT, FIB or PDW (P< 0.05), there was a significant negative correlation with the value of PLT or PCT (P<0.05). ROC analysis showed that the sensitivity of serum BAFF level was 98.3%, the specificity was 66.7%, and the cutoff value was 198.3 pg/mL. The multiple Logistic regression analysis had showed that BAFF level was an independent influencing factor on adverse outcomes of pregnant women with HDCP. Conclusion: Serum BAFF level of pregnant women with HDCP is increased and is closely related to their blood index. The detection of serum BAFF level is helpful for early diognosing hypertensive disorder complicating pregnancy and pre thrombotic state of pregnant women, so it can be used as an important index for diagnosing hypertensive disorder of pregnant women early.
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