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| Effect of Yi Qi Yang Yin decoction combined with insulin for treating pregnant women with gestational diabetes mellitus and dual deficiency of QiYin, and anaysis its influence on serum adipokine levels |
| Nanjing Pukou District Central Hospital，Nanjing, Jiangsu |
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Abstract Objective: To explore the clinical value of Yi Qi Yang Yin decoction combined with insulin. Methods: 92 pregnant women with gestational diabetes mellitus (GDM) and dual deficiency of Qi-Yin who had admitted in Nanjing pukou district central hospital between Aug 2015 and Aug 2017 were selected as study subjects, and they were divided randomly into observation group (46 patients) and control group (46 patients). The women in control group were treated by insulin, and the women in observation group were treated by Yi Qi Yang Yin decoction combined with insulin. The changes of blood glucose and serum adipokine levels before treatment and before delivery, the occurrence of adverse reactions of all women during treatment and their pregnancy outcomes were observed in the two groups. Results: There were no significant different in blood glucose and serum adipokines levels before treatment between the two groups (P>0.05). Before delivery, the levels of fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2h PBG), leptin (LP), petinolbinding protein-4 (RBP-4) of women in observation group were significant lower than those of women in control group(P<0.05), but the level of adiponectin (ADPN) of women in observation group was significant higher than that of women in control group(P<0.05).The incidence of adverse reactions of women in observation group was 10.9%, which had no significant difference (P>0.05) from that of women in control group (15.2%). The cesarean section rate, and the incidence of premature delivery, polyhydramnios, and macrosomia of women in observation group were significant lower than those of women in control group (P<0.05). The incidence of postpartum hemorrhage, neonatal asphyxia, and neonatal hypoglycemia had no statistically significant different between the two groups.Conclusion: When Yi Qi Yang Yin decoction combined with insulin is used for treating women with GDM and dual deficiency of Qi-Yin, it can effectively control blood glucose, regulate the level of adipokines, and improve pregnancy outcomes, and it has high safety, so it is worth clinical application.
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