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| Effects of clomiphene or tamoxifen on sex hormone level and pregnancy rate of infertile women with polycystic ovary syndrome |
| The Red Cross Hospital of Qinghai, Xining City, Qinghai Province |
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Abstract Objective: To investigate the effects of clomiphene or tamoxifen on the level of sex hormone and pregnancy rate of infertile women with polycystic ovary syndrome (PCOS). Methods: 106 infertile women with PCOS who had admitted in the red cross hospital of Qinghai from July 2015 to July 2017 were randomly divided into two groups,which included 53 cases in observation group (treated by tamoxifen)and 53 cases in control group (treated by clomiphene). The follicle diameters on HCG day were recorded, the endometrial thickness and sex hormone level were monitored during follicular period, ovulation period and luteal phase, ovulation was observed, and pregnancy rate and abortion rate were evaluated. Results: There were no statistical difference in the time to HCG and follicle diameter on HCG day of women between the two groups (P>0.05). There were no statistical signifficent different in the levels of T, E2, P, and LH of women during follicular phases of women between the two groups (P>0.05), and there were also no statistical signifficent different in the levels of LH and T during ovulation and luteal phase of women between the two groups (P>0.05). The levels of E2 and P during ovulation and luteal phase of women in observation group were significant lower than those of women in control group (P<0.05). The endometrial thickness during ovulation and luteal phase of women in observation group were significant thicker than those of women in control group (P<0.05).There was no statistical difference in the rate of ovulation between the two groups (P>0.05). The pregnancy rate of women in observation group was significant higher than that of women in control group (P<0.05), but the early abortion rate and incident of adverse drug reaction of women in observation group were significant lower than those of women in control group (P<0.05). Conclusion: Both clomiphene and tamoxifen have good ovulation effect when treating infertile women with PCOS. Clomiphene has great influence on sex hormones level, and has adverse affect on thickness of endometrium, so the infertile women treated by clomiphene have lower pregnant rate. Tamoxifen has little effect on sex hormones, which can improve pregnancy rate, can promote gestational sac and embryo development, and can reduce early abortion rate.
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