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| Effect of diphereline combined with estradiol valerate for treating endometriosis and its influence on inflammatory factors |
| 1.Wenchang People's Hospital, Wenchang, Hainan, 571300; 2. Hainan Medical University The First Affiliated Hospital |
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Abstract Objective: To explore the clinical effect of diphereline combined with estradiol valerate for treating endometriosis. Methods: A total of 94 patients with endometriosis from November 2015 to November 2017 were selected, and they were divided into two groups by random number table (47 cases in each group). The patients in control group were given Diphereline treatment, and the patients in observation group were given estradiol valerate add-back therapy except Diphereline treatment. The clinical efficacy of women in the two groups before and after treatment were observed, and the incidence of adverse reaction of women during treatment in both groups were also observed. Results: 3 months after treatment, visual analogue scale (VAS), estradiol (E2) level, bone mineral density (BMD), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin- 8 (IL-8) of patients in the two groups were significantly different when compared to those before treatment (P<0.05), but there was no significant difference in above indexes of patients between the two groups before treatment (P>0.05). 3 months after treatment, the level of E2 and the BMD of patients in observation group were significantly higher than those of patients in control group (P<0.05), but the VAS score and the level of TNF-α, IL-6 and IL-8 had no significant difference between the two groups (P>0.05). During treatment, the incidences of tidal sweats, vaginal dryness, joint pain and mood swings of patients in observation group were significant lower than those of patients in control group (P<0.05), but there were no significant difference in incidences of sexual desire and fatigue between the two groups (P > 0.05). Conclusion: Diphereline combined with estradiol valerate for treating endometriosis can significantly alleviate the pain symptoms, reduce the level of inflammatory factors, and has excellent curative effect. It can also regulate estrogen levels and inhibit bone loss, and had less adverse reaction. It is worthy of clinical application.
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