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Abstract Objective:To investigate the changes of trace element levels of obese infertile men's seminal plasma, and to analyze its correlation with semen parameters. Methods: 124 subjects were divided into normal weight group (n = 39), overweight group (n = 45), or obesity group (n = 40) according to body mass index (BMI). CASA semen analysis system was used to analyze the parameters of semen, and the levels of zinc(Zn), copper(Cu), selenium(Se), cadmium(Ca), lead(Pb), iron(Fe) and manganese(Mn) in the seminal plasma were detected by inductively coupled plasma atomic emission spectrometry. Then the relationships between the changes of trace element levels and BMI or semen parameters were analyzed. Results: Compared with normal weight group, the forward motility sperm rate(FR) of men in overweight group and in obesity group had decreased significantly (P<0.05). Compared with the normal weight group, the levels of Cd, Pb and Zn in semen of men in the overweight group and in obese group were significantly increased (P<0.05), but the Se level was significantly lower (P<0.05). The correlation analysis found that BMI was positively correlated with the level of Cd, Pb, Fe and Zn levels (P<0.05), but was negatively related to the level of Se (P<0.05). The level of Zn in the seminal plasma was negatively correlated to FR (P<0.05). The level of Fe in the seminal plasma was negatively correlated to sperm volume, but positively correlated to total sperm count (P<0.05). Conclusion: The levels of trace elements in the seminal plasma of obese infertility male have changed, and the changes may affect the quality of semen.
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