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Abstract Objective: To investigate the chang of thyroid function index of early pregnant women. Methods: 1460 early pregnant women presented to aerospace center hospital from August 2016 to July 2017 were enrolled in study group, and 472 nonpregnant women were included in control group at the same time. Serum levels of total triiodothyronine (TT3), total tetraiodothyronine(TT4), free triiodothyronine (FT3), free tetraiodothyronine(FT4), hyroid stimulating hormone(TSH) and thyroid peroxidade antibody (antiTPO) of all included women were detected by chemiluminescence method, and were compared between the two groups. Results: Compared with women in control group, serum levels of TT3, TT4, FT3, TSH and antiTPO of pregnant women in study group were statistical significant different(P<0.05), serum levels of TT3 and TT4 were higher, while serum levels of FT3, TSH and antiTPO were lower. Thyroid dysfunction rate of pregnant women in study group was 31.7%, and most of them were subclinical hypothyroidism (13.1%) and pure antiTPO positive (13.2%). The rate of pure antiTPO positive of women in control group was 22.7%, which was significant higher than that of women in study group. And the levels of other thyroid function index of women in control group were lower than those of women in study group. Conclusion: The serum levels of thyroid hormone of early pregnant women are different from those of nonpregnant women, and most of early pregnant women have subclinical hypothyroidism and pure antiTPO positive. Therefore, serum thyroid hormone levels detected early for pregnant women can help diagnosing thyroid dysfunction and giving intervention in time.
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