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Abstract Objective: To investigate the clinical significance of expression of FOXM1, hTERC or Cmyc gene in screening HPVpositive cervical cancer. Methods: 360 women with positive result who tested HPV in Shiyan maternal and child health care hospital from January 2015 to January 2016 were rolled in this study. Among them, 120 women with cervical cancer were in cervical cancer group, 120 women with CIN IIII were in CIN group, and 120 women with uterine benign lesions were in control group. Immunohistochemistry was used to detect the expression of FOXM1, hTERC or Cmyc gens by MaxVision immunohistochemistry. Results: The positive rate of the three genes showed the characteristic of increasing from normal tissue to CIN tissue, and to cervical cancer. In cervical cancer, there was correlation in the expression of FOXM1, hTERC and Cmyc genes, but the correlation of expression of FOXM1, hTERC and Cmyc genes was not found in normal cervical tissue or cervical tissue with CIN. The expression of FOXM1 gene was related to the depth of invasion, clinical stage, differentiation degree and lymph node metastasis of cervical cancer. The expression of hTERC gene was related to the depth of invasion and differentiation of cervical cancer, and the expression of Cmyc gene was only related to the depth of invasion of cervical cancer (P <0.05). Conclusion: The expression of FOXM1, hTERC and Cmyc genes may play an important role in the carcinogenesis and progression of cervical cancer, which maybe develope a new idea for screening and prognosis evaluation of HPVpositive cervical cancer.
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