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| Analysis of high risk HPV infection situation and immune cell function of middle or late pregnant women with cervical intraepithelial neoplasia |
| Xianyang Hospital Affiliated to Yan 'an University, Shaanxi |
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Abstract Objective: To investigate high risk HPV infection situation and level of T cells subgroup in peripheral blood of middle or late pregnant women with cervical intraepithelial neoplasia (CIN). Methods: From June 2014 to June 2016, 126 middle or late pregnant women with CIN who had come to Xianyang hospital affiliated to Yan 'an university for treatment were recruited into observation group, and 131 middle or late pregnant women without CIN were in control group. The positive rate of different type of highrisk HPV, rate of highrisk HPV negative conversion, DNA load of HPV and function of immune cell of all women were detected. Results: The rates of highrisk HPV infected pregnant women in observation group were HPV16 (78.57%), HPV18 (32.5%), HPV31 (8.7%), HPV33 (206%) and HPV58 (2.4%). In control group, the rates of highrisk HPV infected pregnant women were HPV16 (16.3%) and HPV31 (5.3%). The positive rate of HPV16, HPV18 and HPV33 of women in observation group were significant higher than those of women in control group (P<0.05). Compared to those of women in control group at six months after labor, in observation group, with increasing degree of CIN of women, highrisk HPV infection positive rate increased, the positive rate of high risk HPV infected increased, and rate of high risk HPV nature negative conversion decreased, DNA load of high risk HPV increased, which had all statistically significant different (P<0.05). In observation group, the number of CD4、CD4/CD8 of women with different CIN stage had statistically significant different before labor (F=3.299,3.207, P<0.05), and number of CD4 of women with different CIN stage had statistically significant different after six months postpartum (F=13.11, P<0.001). Conclusion: DNA load of highrisk HPV and level of T lymphocyte subsets of middle or late pregnant women with CIN detected early can help for diagnosis and prognosis monitoring of highrisk HPV infected in middle and late pregnant women. Improving cellular immune function can inhibit HPV infected.
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