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Abstract Objective: To explore effects of using LEEP cervical conization combined with restructured alpha 2 b interferon suppository to treat cervical intraepithelial neoplasias ( CIN ) ，and to provide clinical proof for further treatment. Methods: From January 2012 to January 2015 ,120 patients with CIN were randomly divided into the observation group and the control group (60 cases in each group). The cases of the two groups all had been operated by LEEP cervical conization, and the observation group had preoperative and postoperative application of restructured alpha 2 b interferon suppository, while the control group only had postoperative using restructured alpha 2 b interferon suppository. Clinical effects of the two groups were recorded and compared. Results: Six months after treatment in the observation group, the total effective rate was 93.3% significantly higher than that in the control group 76.7%, with statistically significant difference (χ2 = 6.536, P<0.05); And after 1 year followed up, the recurrence rate was 0% in the observation group, which significantly lower than that in the control group 6.7%, with statistically significant difference (χ2= 4.138, P<0.05). In the observation group, intraoperative blood loss, vaginal drainage volume and the average healing time were all significantly shorter than those in the control group, which was statistical significance difference (all P<0.05); And in the observation group after treatment, IgG, IgA, IgM, CD4+, CD4+ / CD8+ levels were all higher than those in the control group, while CD8+ level was lower than that in the control group (all P<0.05). Conclusions: Using LEEP cervical conization combined with restructured alpha 2 b interferon suppository to treat CIN has higher cure rate, as well as lower postoperative recurrence rate, which is worthy of clinical application.
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