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Abstract Objective: To explore the relationship between the gene polymorphism of methylenetetrahydrofolate reductase（MTHFR）C677T，A1298C and methionine synthase reductase（MTRR）A66G among women with abnormal pregnancy history. Methods: A total of 359 women with abnormal pregnancy history (study group) and 1032 controls were included in this study. Oral epithelial cell samples were collected to extract genome DNA, and fluorescence quantitative polymerase chain reaction（FQ-PCR）technique was used to detect gene polymorphism of MTHFR and MTRR and analyze the correlation between MTHFR and MTRR gene polymorphism distribution and the occurrence of undesirable pregnancy. Results: The frequencies of MTHFR 677TT, MTHFR 1298CC and MTRR 66GG homozygous mutation in the study group were statistically significantly higher than those in the control group（χ2＝4.95，P＜0.05；χ2＝5.92，P＜0.05；χ2＝10.73，P＜0.01）; The frequencies of MTHFR 677AA, MTHFR 1298AA and MTRR 66AA homozygous in the study group were statistically significantly lower than those in the control group. Conclusion: The homozygous mutation of MTHFR C677T, MTHFR A1298C and MTRR A66G may be related to the increased risk of abnormal pregnancy.
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