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| Effect of duration of cryopreservation of donor sperm on pregnancy and offspring in artificial insemination by donor |
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Abstract Objective: To explore the effect of the duration of cryopreservation of donor sperm in liquid nitrogen on pregnancy outcome of artificial insemination by donor (AID) and the security of the offspring. Methods: Retrospective analysis of 6038 infertile couples who underwent 14 290 treatment cycles from April 2007 to April 2013 in our center was conducted. The relationship between the duration of cryopreservation of donor sperm (0.5 to 1 year, >1 to 3 years, >3 to 5 years, >5 to 7 years and >7 to 10 years, respectively) and the pregnancy and abortion rates as well as the incidence of birth defects in AID were evaluated. Results: No effect of the duration of cryopreservation of donor sperm on the pregnancy and abortion rates was found (P all>005). The incidence rate of birth defect was 1.33%, and no statistically significant difference was found among different duration of cryopreservation of donor sperm (P all >0.05). Conclusion: Long-term storage of donated sperm in liquid nitrogen maybe safe in AID due to no impact on clinical pregnancy rate, abortion rate and the incidence of birth defect. The effect is similar to those of natural pregnancy.
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