To study the risk factors of the intrauterine infection of full-term pregnant women caused by premature rupture of fetal membranes. Methods: The clinical data of 43 full-term women with the intrauterine infection caused by premature rupture of fetal membranes (in study group) and 107 full-term women without the intrauterine infection (in control group) from January 2020 to January 2022 were selected retrospectively. The risk factors of the intrauterine infection of the fullterm women caused by premature rupture of fetal membranes were analyzed. Results: Univariate analysis showed that there were no significant differences in the age, the body mass index, the history of delivery, the history of induced abortion, the cervical insufficiency, the regular prenatal care during pregnancy, the malnutrition, the left ventricular end-diastolic diameter and the left ventricular contraction of the women between the two groups (P>0.05). There were significant differences in the time from the rupture of fetal membranes to the delivery, the number of vaginal examinations after rupture of membranes, the increased abdominal pressure, the polyhydramnios, and the levels of serum IL-6, PCT and CRP of the women between the two groups (P<0.05). Multivariate unconditional logistic regression analysis showed that the time from the rupture of membranes to the delivery >4h, the vaginal examination after the rupture of membranes >4 times, the increased abdominal pressure, the polyhydramnios, and the abnormal increase of serum IL-6, PCT and CRP levels of the full-term pregnant women were the independent risk factors of their intrauterine infection caused by premature rupture of fetal membranes (all P<0.05). The serum levels of IL-6, PCT and CRP of the full-term women with premature rupture of fetal membranes had increased with the severity of their intrauterine infection, and were positively correlated with the degree of their intrauterine infection (all P<0.05). Conclusion: There are many independent risk factors of the intrauterine infection of the women caused by the premature rupture of fetal membranes, so the target intervention should be carried out according to these risk factors in clinic.