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| Comparative study on the effect of the target-controlled infusion of remimazolam and propofol on the anesthetic effect of patients during gynecological hysteroscopy surgery |
| 1.Zhongshan Sixth People's Hospital, Zhongshan, Guangdong Province, 528437；2.Yangjiang People's Hospital, Yangjiang, Guangdong Province |
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Abstract To compare the effects of the target-controlled infusion (TCI) of remimazolam and propofol for patients during gynecological hysteroscopy surgery on their awakening time, heart rate (HR) and mean arterial pressure (MAP). Methods: 80 patients who wanted hysteroscopic surgery in the hospital were selected and were randomly divided into control group and observation group (40 cases in each group) from August 2022 to October 2023. The patients in the control group were given TCI propofol for anesthesia during surgery, while the patients in the observation group were given TCI remimazolam for anesthesia during surgery. The onset time of anesthesia, the awakening time, the awakening quality evaluated by Aldrete score at 10, 20, and 30 minutes after surgery, the values of HR, MAP, respiratory rate (RR) and oxygen saturation (SpO2), the bispectral index (BIS) at before anesthesia (T0), 3 minutes after anesthesia (T1), dilation (T2) and awakening (T3), the intraoperative sensory motor block, the Ramsay sedation score, the analgesia effect evaluated by visual analog scale(VAS) at postoperative 2 hours, and the anesthesia related adverse reactions rate of the patients were recorded and were compared between the two groups. Results: The onset time of anesthesia (2.27±0.57 min), the awakening time (5.17±1.77 min), the scores of sedation (0.98±0.39 points) and analgesia (3.01±0.29 points) of the patients in the observation group were significantly less than those (2.56±0.68 min, 5.96±1.68 min, 1.24±0.59 points and 3.26±0.15 points) of the patients in the control group (all P<0.05). The Aldrete scores of the patients in the observation group at T0-T3 (7.80±0.41 points, 8.80±0.41 points and 9.00±0.64 points) were significantly higher than those (6.60±0.50 points, 7.60±0.50 points and 8.40±0.50 points) of the patients in the control group. The changes of the values of HR, MAP, RR and SpO2 of the patients in the observation group at T1-T3 were significantly less than those of the patients in the control group (all P<0.05). There were no significant differences in the BIS, the motor block and the anesthesia-related adverse reactions rate of the patients between the two groups (P＞0.05). Conclusion: Both TCI remifentanil and TCI propofol can be used for the gynecological hysteroscopic surgery of the patients. Compared with those of TCI propofol, TCI Remazolam can improve the postoperative awakening and can maintain the perioperative HR MAP, RR and SpO2 values of the patients, and which might have significant advantages in improving the anesthesia efficiency of the patients.
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