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| Influence of the lipemia of pregnant women on their biochemical test results and the correlation between the lipemia of the pregnant women and their adverse pregnancy outcomes |
| 1.Dechang County People's Hospital，Dechang, Sichuan Province, 615500; 2.Dujiangyan Traditional Chinese Medicine Hospital, Dujiangyan, Sichuan Province |
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Abstract To explore the influence of the lipemia of pregnant women on their biochemical test results, and to study the correlation between the lipemia of the pregnant women and their adverse pregnancy outcomes. Methods: A total of 102 pregnant women with hyperlipidemia who received antenatal examination and delivered in the hospital from December 2018 to December 2023 were collected in observation group retrospectively, and 102 normal pregnant women who received antenatal examination and delivered in the same hospital during the same period were selected in control group. The blood samples of the women in the observation group were handled by low temperature and high speed centrifugation, and the changes of the levels of the serum biochemical indexes, such as creatinine, alkaline phosphatase(ALP), creatine kinase isoenzyme(CK-MB), fasting blood glucose, aspartate aminotransferase(AST) and alanine aminotransferase(ALT) of the women in the observation group were compared between before and after handling the blood samples. The adverse maternal and infants outcomes were compared between the two groups. Receiver-operating characteristic(ROC) curve was used to analyze the assessment value of the hyperlipidemia of the women for their adverse pregnancy outcomes. Spearman correlation was used to analyze the correlation between the lipemia of the pregnant women and their adverse pregnancy outcomes. Results: The Cr, ALP, CK-MB, FBG, AST and ALT levels in the blood samples of the women in the observation group after handling the blood samples had decreased significantly, and the blood TC, TG, HDL-C and LDL-C levels of the women in the observation group were significantly higher than those of the women in the control group(all P<0.05). The adverse pregnancy outcomes rate(23.5%) of the women in the observation group was significantly higher than that(6.9%) of the women in the control group(P<0.05), but which had no significant different among the women diagnosed hyperlipidemia during the different gestational weeks in the observation group(P>0.05). The area under the ROC curve, the specificity and the sensitivity of the lipemia detection of the pregnant women with hyperlipidemia for their adverse pregnancy outcomes were 0.720, 57.2% and 90.3%, respectively. The blood lipid levels of the pregnant women with hyperlipidemia were positively correlated with the maternal and fetal adverse outcomes(all P<0.001). Conclusion: The lipemia of the pregnant women has certain influence on the other biochemical test items of the women, and the low temperature and the centrifugal reprocessing for the lipemia samples of the pregnant women has certain effect for decreasing the influence on the other biochemical test items of the women. The pregnant women with lipemia have the higher incidence of adverse pregnancy outcomes.
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