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| Effect of T2-weighted imaging with fat suppression and apparent diffusion coefficient technology for evaluating the situations of lymph node metastasis and lymph vascular space invasion of patients with cervical cancer |
| Fuyang Cancer Hospital, Fuyang, Anhui Province, 236000 |
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Abstract To observe the value of T2-weighted imagnetic resonance with fat suppression sequence(T2WI-FS) and apparent diffusion coefficient(ADC) technology for evaluating the situations of lymph node metastasis(LNM) and lymph vascular space invasion(LVSI) of patients with cervical cancer(CC). Methods: The clinical data of 120 patients with CC confirmed by pathology who had been given hysterectomy combined with pelvic lymph node dissection in the hospital from January 2018 to September 2023 were analyzed retrospectively. All these patients had received MRI and diffusion-weighted imaging(DWI) before surgery. The images of the transverse T2WI-FS and the ADC of these patients were collected. Based on the postoperative pathological examination as the gold standard, the value of T2WI-FS and ADC technology for evaluating the LNM and LVSI of the patients with CC was analyzed. Results: The pathological results showed that 40 of 120 patients with CC had LNM and 80 patients had no LNM. There were 28 patients with LNM detected by T2WI-FS and 72 patients without LNM, there were 32 patients with LNM detected by ADC and 71 patients without LNM, and there were 38 patients with LNM detected by T2WI-FS combined with ADC and 79 patients without LNM. The accuracy, the sensitivity, the specificity, the positive predictive value and the negative predictive value of T2WI-FS combined with ADC for diagnosing the LNM of the patients with CC were 97.5%, 95.0%, 98.8%, 97.4% and 97.5%, respectively, which were all significantly higher than those of T2WI-FS or ADC alone(P<0.05). The pathological results showed that there were 49 patients with positive LVSI and 71 patients with negative LVSI in 120 patients with CC. There were 37 patients with positive LVSI and 60 patients with negative LVSI diagnosed by T2WI-FS, there were 39 patients with positive LVSI and 61 patients with negative LVSI diagnosed by ADC, and there were 46 patients with positive LVSI and 69 patients with negative LVSI diagnosed by T2WI-FS combined with ADC. The accuracy, the sensitivity, the specificity, the positive predictive value and the negative predictive value of T2WI-FS combined with ADC for diagnosing the LVSI of the patients with CC were 95.8%, 93.9%, 95.8%, 95.8% and 95.8%, respectively, which were all significantly higher than those of T2WI-FS or ADC alone(P<0.05). Conclusion: The value of T2WI-FS combined with ADC for evaluating the LNM and LVSI of the patients with CC is higher, and which can provide the evidences for developing the clinical treatment plan and evaluating the prognosis of the patients.
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