To explore the related factors of pelvic floor dysfunction after transabdominal total hysterectomy, and to provide reference for the countermeasures. Methods: The clinical data of 84 patients who had undergone total hysterectomy in hospital from January 2020 to November 2022 were collected retrospectively. These patients were divided into group A (32 case with pelvic floor dysfunction (PDF)) and group B (52 case without PDF) according to whether the patients with PDF complicated or not in 1 year after operation. The relevant clinical data of the patients in the two groups were collected. Univariate analysis was used to explore the possible influencing factors of the PDF occurrence of the patients after total hysterectomy, and then the independent influencing factors of the PDF occurrence of the patients were identified by multivariate logistic regression analysis. Results: In group A, there were 6 cases with simple pelvic organ prolapse, 4 cases with simple stress urinary incontinence, 3 cases with simple sexual dysfunction and 1 case with simple fecal incontinence, and there were 18 cases with more than two kinds of PDF. There were significant differences in the age, the body mass index, the menopause situation, the gravidity, the parity, the intraoperative blood loss, the time of postoperative indwelling catheter, and the early weight bearing situation of the patients between the two groups (P<0.05). Multivariate analysis showed that the menopause and the intraoperative blood loss of the patients were not the independent influencing factors of their PDF occurrence after transabdominal total hysterectomy (P>0.05). The advanced age (OR=1.270, 95%CI 1.036-1.558), the higher body mass index (OR=2.672, 95%CI 1.376-5.190), the more gravidity (OR=8.947, 95%CI 2.566-31.193), the more parity (OR=12.302, 95%CI 3.039-49.802), the longer time of postoperative indwelling catheter (OR=1.561, 95%CI 1.120-2.177) and the early weight bearing (OR=3.713, 95%CI 1.628-8.470) of the patients with transabdominal total hysterectomy were the independent risk factors of their PDF occurrence (all P<0.05). Conclusion: The PDF occurrence of the patients after transabdominal total hysterectomy is related to their age, body mass index, gravidity, parity, time of postoperative indwelling catheter and early weight-bearing. It is suggested that the high-risk patients with PDF should be identified based on the above factors, so as to enhance the perioperative management of the patients.