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| Effects of high intensity focused ultrasound (HIFU) ablation for treating patients with adenomyosis on their uterine artery blood flow parameters values, sex hormones levels and pain |
| Wanning People's Hospital, Wanning, Hainan Province, 571500 |
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Abstract To explore the effect of high intensity focused ultrasound (HIFU) ablation for treating patients with adenomyosis, and to study its influence on the uterine artery blood flow parameters values, sex hormones levels and pain of the patients. Methods: A retrospective analysis was performed on 118 patients with adenomyosis admitted to hospital from June 2022 to June 2023. According to the different treatment methods, these patients were divided into the observation group (60 patients with treatment of HIFU ablation) and the control group (58 patients with treatment of lesion resection). The preoperative and postoperative menstrual blood volume evaluated by pictorial blood loss assessment chart (PBAC), the dysmenorrhea degree evaluated by visual analogue score (VAS), the uterine artery blood flow parameters, such as perfusion index (PI), resistance index (RI) and uterine arterial blood flow volume (BFV), the level of sex hormones, such as follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2), and the situations of the adverse reactions, fertility intention and the adenomyosis recurrence of the patients were compared between the two groups. Results: There were no statistically significant differences in the postoperative menstrual blood volume evaluated by PBAC in 3 and 6 months after surgery, the VAS score of dysmenorrhea degree and the adverse reactions rate (5.0% vs. 3.5%) of the patients between the two groups (P>0.05). The VAS score of surgical pain (3.48±1.12 points) of the patients in the observation group in 1d after surgery was significantly lower than that (4.20±1.32 points) of the patients in the control group (P<0.05). In the 6th month after surgery, the PI and BFV values, and the levels of FSH, LH and E2 of the patients in the two groups were significantly lower than those before operation, and the RI value of the patients in the two groups was significantly higher than that before operation, but all of which of the patients had no significant differences between the two groups. There was 1 patient with adenomyosis recurrence in both groups, and the adenomyosis recurrence rate of the patients had no significant difference between the two groups (all P>0.05). Conclusion: HIFU ablation for treating the patients with adenomyosis has effectiveness, which has the same effect as the surgical treatment, but it can reduce the of postoperative pain degree of the patients.
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