To explore the application effect of the mobile health intervention based on the health belief model for patients with ovarian cancer (OC) after operation. Methods: 156 patients after OC operation were selected and were divided into experimental group and control group (78 cases in each group) according to the random lottery method from May 2020 to May 2023. The patients in the control group were given routine nursing intervention, and the patients in the experimental group were given mobile health intervention based on health belief model combined with the routine nursing intervention. The patients in both groups were intervened until 3 months after operation. The self-efficacy score evaluated by strategies used by people to promote health (SUPPH), the selfmanagement ability score evaluated by the exercise of self-care agency scale (ESCA), the negative emotions score evaluated by self-rating anxiety scale (SAS), and self-rating depression scale (SDS), and the situations of compliance and complications of the patients were compared between the two groups. Results: After intervention, the scores of the different dimensions of SUPPH and ESCA of the patients in the experimental group were significantly higher than those of the patients in the control group. The scores of SDS (45.31±5.45 points) and SAS (43.55±4.61 points) of the patients in the experimental group were significantly lower than those (50.41±6.38 points and 48.62±5.47 points) of the patients in the control group. The good rate (66.7%) and moderate rate (26.9%) of the compliance of the patients in the experimental group were significantly higher than those (47.7% and 28.2%) of the patients in the control group.  The incidence of complications (5.1%) of the patients in the experimental group was significantly lower than that (15.4%) of the patients in the control group (all P<0.05). Conclusion: The mobile health intervention based on the health belief model for the patients after OC operation can enhance their self-efficacy and selfmanagement ability, reduce their unhealthy mood, improve their compliance and reduce the incidence of their complications.