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| Influence factors of the onset of gestational diabetes mellitus of pregnant women and their correlation with the adverse pregnancy outcomes |
| Affiliated to Ningbo University Women and Children's Hospital, Ningbo, Zhejiang Province, 315000 |
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Abstract To explore the influencing factors of the onset of gestational diabetes mellitus (GDM) of pregnant women, and to study their correlation with the adverse pregnancy outcomes of the women. Methods: The clinical data of 120 pregnant women with GDM (in study group) and 120 healthy pregnant women (in control group) that had been accepted the antenatal examinations in hospital from February 2021 to February 2023 were selected in this study. The clinical factors and the laboratory indicators of the women were compared between the two groups. The influencing factors of the GDM occurrence of the women were analyzed by multivariate logistic regression analysis. The rate of the adverse pregnancy outcomes of the women was compared between the two groups. Results: The proportions of the age ≥35 years old, the body mass index (BMI) during pregnancy ≥28kg/m2, and the weight gain during pregnancy ≥8kg, and the levels of malondialdehyde (MDA), triglyceride (TG), and total cholesterol (TC) of the women in the study group were significantly higher than those of the women in the control group, but the level of superoxide dismutase (SOD) of the women in the study group was significantly lower (all P<0.05). Logistic regression analysis showed that the age ≥35 years old, the gestational BMI≥28kg/m2, the gestational weight gain ≥8kg, the abnormal increase of the levels of MDA, TG and TC of the women were the influencing factors of their GDM occurrence, and the increase of the SOD level of the women was the protective factor of their GDM occurrence. The incidences of the macrosomia, premature rupture of membranes, cesarean section, neonatal jaundice and premature delivery of the women in the study group were significantly higher than those of the women in the control group (P<0.05). Conclusion: The GDM occurrence of the pregnant women is associated with their age, their gestational BMI and weight gain, and their abnormal levels of MDA, TG, TC, and SOD. The GDM occurrence of the pregnant women can increase the risk of their adverse pregnancy outcomes.
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