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| Coagulation factor VIII activity and plasminogen activator inhibitor-1 level of pregnant women with threatened miscarriage during the first trimester of pregnancy and their influence on the tocolytic outcomes |
| Qingdao Jiaozhou Central Hospital, Jiaozhou, Shandong Province, 266300 |
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Abstract To investigate the predictive value of the coagulation factor VIII (FVIII) activity and plasminogen activator inhibitor-1 (PAI-1) level of pregnant women with threatened miscarriage during the first trimester of pregnancy for their tocolytic outcomes. Methods: The clinical data of 345 pregnant with threatened miscarriage during the first trimester of pregnancy from January 2020 to December 2022 were analyzed retrospectively. According to the tocolytic outcomes, these women were divided into group A (124 cases with the failure of tocolytic outcomes) and group B (221 cases with the successful tocolytic outcomes). The FVIII activity and the levels PAI-1, beta human chorionic gonadotropin (β-hCG), serum estradiol(E2) and progesterone (P) of the women in the two groups were detected. The endometrial thickness (ET) of the women in the two groups was examined by ultrasound. Multivariate logistic regression analysis was conducted to identify the influencing factors of the successful tocolytic outcomes of the pregnant women with threatened miscarriage during the first trimester of pregnancy. Results: The FVIII activity (168.31±25.84%) and the PAI-1 level (54.39±6.05μg/l) of the women in group A were significantly higher than those (138.64±24.61% and 49.31±5.87μg/l) of the women in group B. The ET value (10.06±3.26 mm) and the levels of β-hCG (1763.86±706.77U/L), E2 (1051.16±369.57 poml/L) and P (32.96±15.72 noml/L) of the women in group A were significantly lower than those (12.55±1.91 mm, 3299.46±1831.59U/L, 3571.36±1126.29 poml/L and 64.38±17.24 noml/L) of the women in group B (all P<0.05). Multivariate logistic regression analysis showed that the increase of the FVIII activity and the decrease of the levels ofβ-hCG, E2 and P were risk factors for the successful tocolytic outcomes of the pregnant women with threatened miscarriage during the first trimester of pregnancy (P<0.05), while the PAI-1 level was not a risk factor for their successful tocolytic outcomes. Conclusion: The increase of FVIII activity of the pregnant women with threatened miscarriage during the first trimester of pregnancy affects their success of tocolysis, which can be used as a reference, so as to reduce the risk of the blind tocolysis in clinical practice.
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