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| Expressions of β-actin and high mobility protein A2 in the endometrial adenocarcinoma tissues of patients and their correlation with the prognosis of the patients |
| 1. Tangshan Maternity and Child Health Care Hospital, Hebei Province, 063000；2. Nanhu Hospital, Tangshan City |
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Abstract To investigate the expressions of β-actin (ACTB) and high mobility protein A2 (HMGA2) in the endometrial adenocarcinoma tissues of patients, and to study their correlation with the prognosis of the patients. Methods: A total of 206 patients with endometrial adenocarcinoma who had been treated in hospital from October 2017 to October 2020 were selected in this study. The expressions of ACTB and HMGA2 in the endometrial adenocarcinoma tissues and in the adjacent tissues of endometrial adenocarcinoma were detected by real-time fluorescent quantitative polymerase chain reaction. The expression differences of ACTB and HMGA2 in the endometrial adenocarcinoma tissues were compared among the patients with different pathological characteristics. The patients were followed up by telephone regularly after surgery until October 2022. The correlation between the expressions of ACTB and HMGA2 in the endometrial adenocarcinoma tissues of the patients and their prognosis was analyzed. Results: The expression levels of the ACTB mRNA (3.65±1.09) and the HMGA2 mRNA (5.03±1.46) in the endometrial adenocarcinoma tissues of the patients were significantly higher than those (1.12±0.36 and 1.65±0.47) in their corresponding adjacent tissues of the endometrial adenocarcinoma (P<0.05). The expressions of the ACTB mRNA and the HMGA2 mRNA in the endometrial adenocarcinoma tissues of the patients with the TNM stage Ⅲ, the deep invasion and the pelvic lymph node metastasis of the endometrial adenocarcinoma were significantly higher than those of the patients with the TNM stage Ⅰ to Ⅱ of adenocarcinoma and without pelvic lymph node metastasis (P<0.05). The median follow-up was 48 (24-60) months, and there were 62 cases died during the follow-up period. The overall survival rates of the patients with the endometrial adenocarcinoma and with the high expressions of ACTB mRNA and HMGA2 mRNA were 59.1% and 61.3%, and which were significantly lower than those (81.2% and 79.0%) of the patients with endometrial adenocarcinoma and with the low expressions of ACTB mRNA and HMGA2 mRNA (P<0.05). Statistical analysis showed that the pelvic lymph node metastasis and the high expressions of ACTB mRNA and HMGA2 mRNA of the patients with the endometrial adenocarcinoma were the independent risk factors of their adverse prognosis (P<0.05). Conclusion: The expressions of ACTB mRNA and HMGA2 mRNA in the endometrial adenocarcinoma tissues of the patients are up-regulated, which are associated with the malignant progression of the endometrial adenocarcinoma and the low overall survival rate of the patients.
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