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| Effects of remifentanil combined with ciprofol for anesthesia during laparoscopic myomectomy of patients on their hemodynamic parameters and inflammatory factors levels |
| Ningde Hospital Affiliated to Ningde Normal University, Ningde, Fujian Province, 352100 |
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Abstract To explore the effects of remifentanil combined with ciprofol for anesthesia during laparoscopic myomectomy of patients on their hemodynamic parameters and inflammatory factors levels. Methods: 110 patients who wanted laparoscopic myomectomy were randomly divided into group A and group B (55 cases in each group) from October 2022 to September 2023. The patients in group A received anesthesia with remifentanil combined with ciprofol during operation, while the patients in group B received anesthesia with remifentanil combined with propofol during operation. The hemodynamic indicators, the awakening quality, the inflammatory factor levels, the cognitive function (MMSE score) and the adverse reactions of the patients in the two groups were observed. Results: The values of the mean arterial pressure, the heart rate and the blood oxygen saturation of the patients in group A were significantly higher than those of the patients in group B. The time of the spontaneous breathing recovery (5.25±1.29 min), the awakening time (7.21±1.86 min), the orientation recovery time (20.56±2.83 min) and the extubation time (24.37±3.01 min) of the patients in group B were significantly shorter than those (7.33±1.85 min, 12.82±2.23 min, 25.38±3.71 min and 32.62±3.67 min) of the patients in group B. The levels of interleukin-6 and tumor necrosis factor-α of the patients in the two groups in 1 day after operation had increased significantly, but which (71.53±10.02 ng/L and 12.23±2.96 ng/L) of the patients in group A were significantly lower than those (90.24±12.84 ng/L and 17.65±3.58 ng/L) of the patients in group B. The MMSE score of the patients in the two groups had decreased significantly, but which (27.04±1.00 points) of the patients in group A was significantly higher than that (25.15±1.17 points) of the patients in group B. The incidence of the adverse reactions (5.5%) of the patients in group A was significantly lower than that (18.2%) of the patients in group B (all P<0.05). Conclusion: The application of remifentanil combined with ciprofol in the laparoscopic uterine myomectomy of the patients can help to stabilize their intraoperative hemodynamic indicators, improve their awakening quality, reduce their inflammatory reactions and cognitive impairment, and with the fewer adverse reactions.
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