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| Effect of nasal continuous positive airway pressure sequential humidified high flow nasal cannula oxygen for treating neonates with pneumonia complicated with respiratory failure |
| Luzhou People's Hospital, Luzhou, Sichuan Province, 646000 |
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Abstract To explore the effect of nasal continuous positive airway pressure (NCPAP) sequential humidified high flow nasal cannula (HHFNC) oxygen therapy for neonates with pneumonia complicated with respiratory failure (RF). Methods: 102 neonates with pneumonia complicated with RF who wanted receiving the treatment in hospital were selected and were randomly divided into control group (51 neonates with the treatment of NCPAP sequential conventional nasal catheter oxygen therapy) and observation group (51 neonates with the treatment of NCPAP sequential HHFNC therapy) from January 2019 to March 2023. The disappearance time of the clinical symptoms, and the values of blood gas indicators, the inflammatory factors levels and the immune function after 24 hours of treatment of the neonates were compared between two groups. Results: The disappearance time of the clinical symptoms of the neonates in the observation group was significantly shorter than that of the neonates in the control group. After 24 hours of treatment, the values of the blood oxygen partial pressure, the oxygenation index and the pH of the neonates in the two groups had increased significantly, and which (76.36±7.28 mmHg, 204.75±20.15mmHg and 7.25±0.59) of the neonates in the observation group were significantly higher than those (72.57±7.05mmHg, 193.07±19.47mmHg and 6.93±0.51) of the neonates in the control group. The respiratory rate (51.43±3.67 times/min) of the neonates in the observation group was significantly lower than that (53.82±4.16 times/min) of the neonates in the control group. The levels of inflammatory factors and immunoglobulin of the neonates in the two groups had decreased significantly. The
levels of C-reactive protein (9.25±1.06 mg/L), neutrophil to lymphocyte ratio (1.22±0.31) and procalcitonin (1.17±0.31 ng/L) of the neonates in the observation group were significantly lower than those (10.84±1.27 mg/L, 1.48±0.36 and 1.41±0.45ng/L) of the neonates in the conventional group (all P<0.05). Conclusion: NCPAP sequential HHFNC for treating the neonates with pneumonia complicated with RF can shorten the improvement time of their clinical symptom, regulate their blood gas indicators and immune function, and relieve their inflammatory response.
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