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| Effects of fentanyl combined with remazolam for anesthesia during painless hysteroscopy diagnosis and treatment of patients on their hemodynamics and recovery quality |
| 1.Huili People's Hospital, Huili, Sichuan Province, 615100; 2. The Fifth People's Hospital of Chengdu, Sichuan Province; 3. Affiliated Hospital of Chengdu University, Chengdu, Sichuan Province |
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Abstract To explore the effects of fentanyl combined with remimazolam for anesthesia during painless hysteroscopy diagnosis and treatment of patients on their hemodynamics and recovery quality. Methods: 60 patients who wanted painless hysteroscopic diagnosis and treatment were randomly divided into two groups from November 2022 to October 2023. 30 patients in group A received anesthesia with fentanyl combined with propofol, while 30 patients in group B received anesthesia with fentanyl combined with remimazolam. The rest of the anesthesia methods of the patients in the two groups were the same. The values of hemodynamics (mean arterial pressure, heart rate), the awakening quality (respiratory recovery, directional force recovery, and eye-opening time), the pain degree evaluated by VAS score, the levels of oxidative stress response, such as malondialdehyde (MDA) and superoxide dismutase (SOD), and the rates of adverse reactions (hypotension, respiratory depression, hypoxemia and intraoperative physical activity) of the patients in the two groups were observed. Results: The values of mean arterial pressure and heart rate of the patients in group B at different time points of anesthesia were significantly higher than those of the patients in group A. The time of breathing recovery (4.99±0.87 min), orientation recovery (12.36±1.67 min) and eye opening (12.00±1.13 min) of the patients in group B were significantly shorter than those (7.87±1.01 min, 15.25±2.16 min and 15.74±1.58 min) of the patients in group A. The VAS score of the patients in group B at 1h (3.01±0.37 points) and at 3h after operation (3.32±0.65 points) were significantly lower than those (3.37±0.56 points and 4.05±0.81 points) of the patients in group A. The MDA level (18.73±2.12 mmol/L) of the patients in group B was significantly lower than that (24.82±2.55 mmol/L) of the patients in group A. The SOD level (320.85±29.61 U/ml) of the patients in group B was significantly higher than that (275.37±27.97 U/ml) of the patients in group A. The total incidence of adverse reactions (6.7%) of the patients in group B was significantly lower than that (26.7%) of the patients in group A (all P<0.05). Conclusion: Fentanyl combined with remazolam for anesthesia during painless hysteroscopy diagnosis and treatment of the patients has the good effectiveness, and which can stabilize their hemodynamics, improve their awakening quality, reduce their postoperative pain degree and oxidative stress reactions, and reduce their adverse reactions, and which can improve the effectiveness and safety of anesthesia to a certain extent.
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