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| Effect of the insulin aspartate used combined with the individualized diet and exercise guidance for controlling the blood glucose level of pregnant women with gestational diabetes mellitus |
| Rugao People's Hospital, Nantong, Jiangsu Province，226500 |
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Abstract To observe the effect of the insulin aspartate used combined with the individualized diet and exercise guidance for controlling the blood glucose level of pregnant women with gestational diabetes mellitus (GDM). Methods: 101 pregnant women with GDM were included and were divided into observation group (50 cases) and control group (51 cases) by random number table method from January 2020 to March 2023. The women in the control group were treated with conventional insulin, and the women in the observation group were treated with insulin aspartate combined with individualized diet and exercise guidance. The changes of the levels of the blood glucose indexes, such as fasting blood glucose (FBG), 2h postprandial blood glucose (2hPBC), glycated hemoglobin (HbAlc) and other, the values of islet function indexes, such as fasting insulin (FINS), homeostasis model islet β cell function index (HOMA-β), homeostasis model insulin resistance index (HOMA-IR) and other, and the levels of oxidative stress indexes, such as oxide dismutase (SOD) and reactive oxygen species (ROS), glutathione peroxidase (GSH-Px) and other, of the women before treatment and after 3 months of treatment, and the treatment compliance, the treatment satisfaction rate and the incidence of adverse outcomes of the women in the two groups were observed. Results: After 3 months of treatment, the levels of the blood glucose FBG (4.75±0.46 mmol/L), the 2hPBC (5.84±0.60 mmol/L) and the HbAlc (6.05±0.41 %) of the women in the observation group were significantly lower than those (5.61±0.70 mmol/L, 5.84±0.60 mmol/L and 6.47%±0.44%) of the women in the control group. The islet function index and
DOI:10.3969/j.issn.1004-8189.2024.02.020 oxidative stress index of the women in the the observation group were significantly better than those of the women in the control group. The compliance rate (98.0%) and the treatment satisfaction rate (96.0%) of the women in the observation group were significantly higher than those (84.3% and 82.4%) of the women in the control group. The rates of maternal adverse outcomes (2.0%) and neonatal adverse outcomes (4.0%) in the control group were significantly lower than those (13.7% and 15.7%) in the control group (all P<0.05). Conclusion: Insulin aspartate combined with individualized diet and exercise guidance for treating the pregnant women with GDM can better help them to control their blood sugar level and improve their islet function, increase their treatment compliance and their treatment satisfaction rate, and reduce their adverse outcomes.
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